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KMID : 0363819770110010049
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Korean Journal of Nuclear Medicine
1977 Volume.11 No. 1 p.49 ~ p.58
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The Effect of Lithium Carbonate in the Treatment of Hyperthyroidism
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李權鈿/Lee, Gwon Jun
李明哲/李弘揆/高昌舜/李文鎬/Lee, Myung Chul/Lee, Hong Kyu/Koh, Chang-Soon/Lee, Munho
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Abstract
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For the assessment of antithyroid effect of lithium carbonate, it was administered to the 17 hyperthyroid and 5 euthyroid patients, who visited the Seoul National University Hospital from Jan. to Aug., 1977. Thyroid function tests were performed just before the administration of Lithium carbonate, 2 weeks and 2 months after lithium treatment. The results were as follows;
1) In the 5 euthyroid patients, no significant changes in thyroid function tests were obtained before and after lithium treatment.
2) In the 17 hyperthyroid patients, the values of the T3 RIA were 370±121ng/dl 2 weeks after
lithium treatment as compared with 506±121ng/dl before the administration, of which the mean 4 percentage fall was 26.9%. T3RU was varied from 56.8±8.0% to 47.3±8. 1% (16.7% in mean
percentage fall), Ts was changed from 24.2±2.4ug/dl to 22.0±4.2ug/dl (9. 1% in mean fall),
,and T7, from 13.82±2.25 to 10. 55±3.12 (23.7% in mean fall).
3) In the 5 hyperthyroid patients, serial thyroid function tests were performed 2 weeks and 2 months later. The mean percentage falls of T3RIA were 36.6 and 61.3%, 2 weeks and 2 months after lithium treatment respectively. Those of T5RU were 17.5 and 35.1%, those of T4 were 20.4 and 44.0%, T7, 35.0 and 60.7%.
4) Approximately 4560% of mean fall in thyroid function tests were obtained within the second week. Normal thyroid function tests were observed in 2 among 17 patients within the second week, and 2 among 5 patients within the second month. 13 patients, however, became clinically euthyroid within the 4th week.
5) Single case of hypothyroidism was experienced, and 5 patients (29.4%) complained mild side effects. Lithium salts could be safely administered to hyperthyroid patients who are allergic to
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thioamides or iodine. Its use is indicated in cases of acute thyrotoxicosis in which it´s necessary to -reduce hormone levels very rapidly, and lithium-thioamides drug combination is a highly effective and safe means of initial routine control of hyperthyroidism.
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